Nutrition

The ProLon Fasting Mimicking Diet: My Experience & Review as a Dietitian

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Written by Diana Licalzi, MS, RD, CDCES

When you're dealing with blood sugar issues and have tried countless diets that promise results but leave you feeling deprived or frustrated, finding something that actually works can feel impossible. As a registered dietitian specializing in diabetes management, I understand this struggle, which is why I decided to personally test the ProLon Fasting Mimicking Diet after seeing promising research on its effects on blood sugar control. Over five challenging but eye-opening days, I lost nearly 5 pounds, experienced a shift in how I thought about food, and discovered an approach that might help people break free from the cycle of blood sugar spikes and crashes that dominate daily life with diabetes or prediabetes.

What Is the Fasting Mimicking Diet?

What makes this approach unique is that, despite consuming these calories, your body remains in a physiologically fasting state. This happens because the precise combination of nutrients tricks your body into activating the same cellular cleanup and renewal processes that occur during complete fasting—without the extreme hunger and potential safety concerns of going without food entirely.

The FMD was developed by Dr. Valter Longo and his team at the University of Southern California's Longevity Institute, and it has accumulated impressive scientific backing, with over 25 years of research and more than 30 clinical trials conducted at prestigious institutions, including Stanford, Harvard, Yale, and the Mayo Clinic.

 

Potential Benefits for Blood Sugar Management

For those managing diabetes or prediabetes, the metabolic benefits of the FMD are particularly compelling. Research has demonstrated that this controlled fasting approach can:

  • Supports healthy metabolic markers like fasting glucose, blood pressure, triglycerides, total and LDL (bad) cholesterol, and CRP (a marker for inflammation) [1]
  • Support cellular cleanup (autophagy) that removes damaged cells that may contribute to metabolic dysfunction.[2]
  • Promote fat-focused weight loss, particularly from the abdominal area, where excess fat is most strongly associated with insulin resistance, without compromising muscle [1,3].
  • Reset your relationship with food, potentially reducing unhealthy cravings and promoting more mindful eating patterns.[4]

These benefits may be especially relevant for adults in their 40s-60s who have struggled with conventional approaches to managing their blood sugar levels. The FMD offers a structured, time-limited intervention that can help break unhealthy eating patterns while delivering measurable metabolic improvements.

My Personal Experience: Day by Day

Day 1: Starting the Journey

On the first day, I received my ProLon kit containing everything I would consume for the next five days. Day 1 provided approximately 1,100 calories—the highest amount of any day in the program. The meals included plant-based soups, olives, crackers, herbal teas, and nut-based bars.

I decided to extend my overnight fast until midday, having my first meal around noon. This helped me distribute my limited food more effectively throughout the rest of the day. The red bell pepper soup was surprisingly tasty, though knowing this was the most caloric day of the program created some anticipatory anxiety about the days ahead.

By evening, I felt a slight hunger, but nothing unmanageable. The nut bars were truly delicious and satisfying, which made saving them for the end of the day an effective strategy for avoiding nighttime hunger.

 

prolon fasting mimicking diet

 

To try ProLon Fasting Mimicking Diet: use code REVOLUTION for 15% off! Or click here: https://prolonlife.com/T2DREVOLUTION

 

Days 2-3: The Challenge Intensifies

Days 2 and 3 reduced my caloric intake to around 700-800 calories, and I definitely felt the difference. Morning hunger came in waves, but staying busy and drinking plenty of fluids—water, herbal teas, and the special L-drink provided in the kit—helped manage the discomfort.

One key component that helps maintain this fasting state is the L-Drink, which contains glycerin that serves as an alternate energy source for your body to use instead of breaking down lean muscle mass during days 2-5 of the program.[3] You'll mix the L-Drink with water in a large 32-ounce bottle, using an amount based on your body weight—the more you weigh, the more L-Drink you'll use, as marked on the packet from top to bottom.

By the afternoon of Day 3, I experienced noticeable energy fluctuations and occasional light-headedness. Taking time to rest when needed and staying well-hydrated proved essential. Despite the challenges, I began noticing some positive changes, including a feeling of lightness and improved mental clarity between hunger phases.

 

Days 4-5: Finding My Rhythm

Interestingly, Days 4 and 5 were actually easier than the earlier days. My hunger sensations diminished noticeably, and my energy levels stabilized. This aligns with what many other people have experienced as well, the body tends to adapt to fasting states after several days, often with a corresponding decrease in hunger hormones.

By the end of Day 5, I had lost nearly 5 pounds and felt a tremendous sense of accomplishment. Beyond the weight loss, I noticed significant improvements in my relationship with food—I appreciated food more intensely and found myself naturally drawn to more nutritious options when I resumed normal eating.

 

Blood Sugar Implications and Considerations

While my primary goal wasn't blood sugar management (since I don't have diabetes), monitoring glucose levels during fasting protocols like the FMD can be particularly valuable for those with type 2 diabetes or prediabetes. Multiple studies have shown that periodic fasting protocols can help reset insulin sensitivity and improve glucose regulation [1].

For example, a 2017 study published in the journal Cell found that the FMD promoted the regeneration of pancreatic cells in mice and improved markers of both type 1 and type 2 diabetes [5]. In human studies, participants with elevated blood sugar levels often see significant improvements in glycemic management and HbA1c after completing multiple cycles of the fasting mimicking diet [6].

However, it's absolutely crucial for individuals with diabetes or prediabetes to consult with their healthcare provider before attempting any fasting protocol, including the FMD. Medication adjustments may be necessary to prevent hypoglycemia, and close monitoring throughout the process is essential.

 

Tips for Success Based on My Experience

If you're considering the ProLon FMD, particularly to help manage blood sugar issues, these strategies helped me complete the program successfully:

  1. Stay busy throughout the day. Distraction is your best friend when hunger strikes.
  2. Structure your eating schedule strategically. Save the most satisfying items (like the nut bars) for times when hunger tends to peak.
  3. Hydrate continuously with water, herbal teas, and the L-drink provided.
  4. Go to bed early and sleep as much as possible—you can't feel hungry while sleeping!
  5. Enlist an accountability partner or share your journey with others for moral support.
  6. Keep your "why" front of mind–whether it's blood sugar control, weight management, or overall health. 

 

 

 

Is the Fasting Mimicking Diet Right for You?

The FMD offers a scientifically backed approach that may be particularly beneficial for adults with type 2 diabetes or prediabetes who have struggled with traditional dietary interventions. Its structured, time-limited nature makes it more accessible than extended water fasting, while still delivering significant metabolic benefits.

That said, this approach isn't appropriate for everyone. Those who are underweight, pregnant or breastfeeding, or have certain medical conditions should avoid fasting protocols. And while the research on fasting for diabetes management is promising, individual responses vary significantly.

The most sustainable approach might be to incorporate periodic FMD cycles (perhaps quarterly) as part of a comprehensive lifestyle strategy that includes regular physical activity, stress management, adequate sleep, and a plant-forward, whole-foods diet between fasting periods.

Remember that lasting health improvements come from consistent habits rather than quick fixes. The FMD may serve as a valuable reset, but the food choices you make in the weeks and months that follow will ultimately determine your long-term metabolic health.

 

To try ProLon Fasting Mimicking Diet: use code REVOLUTION for 15% off! Or click here: https://prolonlife.com/T2DREVOLUTION

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